dual inhibitor — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T2381	Abemaciclib	CDK4/6 dual inhibitor,LY2835219	CDK
	Abemaciclib (LY2835219) is a dual inhibitor of CDK4/6 (IC50=2/10 nM) with selectivity and specificity. Abemaciclib has antitumor activity and is used to treat advanced or metastatic breast cancer.		CDK
T1811	WH-4-023	KIN112,KIN001-112,Dual LCK/SRC inhibitor	Src
	WH-4-023 (Dual LCK/SRC inhibitor) is a potent and orally active Lck/Src inhibitor. It also potently inhibits SIK.		Src
T2431	ID-8	ID8	DYRK
	ID-8, a DYRK inhibitor, sustains embryonic stem cell self-renewal in long-term culture.		DYRK
T15422	GSK-626616		DYRK
	GSK-626616 is a potent and orally bioavailable DYRK3 inhibitor (IC50: 0.7 nM). It inhibits other members of the DYRK family with similar potency. GSK-626616 is a potential therapy for the treatment of anemia.		DYRK
T6257	AZ191		DYRK
	AZ191（IC50 of 17 nM） is an effective and specific DYRK1B inhibitor. The specificity of AZ191 for DYRK1B is about 5- and 110-fold greater over DYRK1A and DYRK2, respectively.		DYRK
T5093	Pim1/AKK1-IN-1	LKB1/AAK1 dual inhibitor,MDK-2275	Pim , Hippo pathway
	Pim1/AKK1-IN-1 (LKB1/AAK1 dual inhibitor) is a potent multi-kinase inhibitor with Kd values of 35 nM/53 nM/75 nM/380 nM for Pim1/AKK1/MST2/LKB1 respectively, and also inhibits MPSK1 and TNIK.		Pim , Hippo pathway
TQ0111	LDN-192960		DYRK , Haspin Kinase
	LDN-192960 is a potent inhibitor of Haspin and DYRK2 (IC50s: 10 nM and 48 nM).		DYRK , Haspin Kinase
T1711	Harmine	Telepathine	MAO , 5-HT Receptor , DYRK
	Harmine (Telepathine) is an alkaloid isolated from seeds of Peganum harmala.		MAO , 5-HT Receptor , DYRK
T7323	BCI-215		Phosphatase
	BCI-215 causes selective cancer cell cytotoxicity in part through non-redox-mediated activation of MAPK signaling		Phosphatase
T11447	GNF4877		GSK-3 , DYRK
	GNF4877 is a potent DYRK1A and GSK3β inhibitor (IC50s: 6 nM and 16 nM). It leads to blockade of nuclear factor of activated T-cells (NFATc) nuclear export and increased β-cell proliferation cells.		GSK-3 , DYRK
T40187	GNF2133		DYRK
	GNF2133 is an effective and selective inhibitor of DYRK1A with IC50s of 6.2 nM. GNF2133 can be used in studies about type 1 diabetes.		DYRK
T2811	Harmine hydrochloride	telepathine hydrochloride	5-HT Receptor , DYRK , GluR
	Harmine hydrochloride (telepathine hydrochloride) is extracted from Peganum Harmala Genus.		5-HT Receptor , DYRK , GluR
T14980	CLK-IN-T3		DYRK , CDK
	CLK-IN-T3 is an inhibitor of CLK1, CLK2, and CLK3 with IC50s of 0.67, 15, and 110 nM. CLK-IN-T3 exhibits anti-cancer activity.		DYRK , CDK
T4199	Desmethyl-VS-5584		PI3K , mTOR
	Desmethyl-VS-5584 is a dimethyl analog of VS-5584, which is a novel and highly selective PI3K/mTOR kinase inhibitor for the treatment of cancer.		PI3K , mTOR
T10616	BRM/BRG1 ATP Inhibitor-1		Epigenetic Reader Domain
	BRM/BRG1 ATP Inhibitor-1 is an allosteric dual Brahma homolog (BRM)/SWI/SNF related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 (SMARCA2) and BRG1/SMARCA4 ATPase activity inhibitor (IC50...		Epigenetic Reader Domain
T4584	BMS-813160	BMS 813160	CCR
	BMS-813160 is the first dual CCR2/CCR5 antagonist to enter Clinical development for cardiovascular.		CCR
T14364	AZ-Dyrk1B-33	3-(2-Methyl-4-pyrimidinyl)-1-(phenylmethyl)-1H-pyrrolo[2,3-c]pyridine	DYRK
	AZ-Dyrk1B-33 (3-(2-Methyl-4-pyrimidinyl)-1-(phenylmethyl)-1H-pyrrolo[2,3-c]pyridine) is a potent and selective Dyrk1B kinase inhibitor with an IC50 of 7 nM.		DYRK
T3707	GNE-3511	GNE3511	DNA Alkylation , MAPK
	GNE-3511 is a potent and selective dual leucine zipper kinase inhibitors.		DNA Alkylation , MAPK
T8409	SYN1143	RON-IN-1,AMG-1	c-Met/HGFR
	SYN1143 (AMG-1) is a potent inhibitor of human RON and c-Met.In vitro kinase assays showed that compound I is a potent inhibitor of human RON and c-Met with IC50s of 9 and 4 nmol/L, respectively.		c-Met/HGFR
T4636	Protein kinase inhibitors 1		Others , DYRK
	Protein kinase inhibitors 1 is a novel inhibitor of HIPK2 with an IC50 of 74 nM and Kd of 9.5 nM.		Others , DYRK